" /> Acalabrutinib - CISMeF





Preferred Label : Acalabrutinib;

NCIt synonyms : Bruton Tyrosine Kinase Inhibitor ACP-196; Benzamide, 4-(8-Amino-3-((2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl)imidazo(1,5-a)pyrazin-1-yl)-N-2-pyridinyl-;

NCIt definition : An orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, acalabrutinib inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.;

UNII : I42748ELQW;

InChIKey : WDENQIQQYWYTPO-IBGZPJMESA-N;

CAS number : 1420477-60-6;

Molecule name : ACP-196; ACP 196;

Codes from synonyms : 7;

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07/05/2025


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