Preferred Label : Quinolinic Acid;
NCIt synonyms : Pyridine-2,3-Dicarboxylic Acid; QA; 2,3-Pyridinedicarboxylic Acid; QUIN;
NCIt definition : An intermediate product of the kynurenine pathway, which is responsible for the conversion
of the amino acid tryptophan into nicotinamide adenine dinucleotide, with potential
neurotoxic activity. If produced in excess, quinolinic acid can cross the blood-brain
barrier (BBB) and function as an N-methyl-D-aspartate (NMDA) receptor agonist, which
may lead to both neuronal damage and neurodegenerative brain disease. The NMDA receptor,
a heterotetrameric, ligand-gated and voltage-dependent glutamate receptor, is critical
for synaptic plasticity, learning and memory.;
UNII : F6F0HK1URN;
CAS number : 89-00-9;
ChEBI ID : CHEBI:16675;
Origin ID : C113236;
UMLS CUI : C0072879;
Currated CISMeF NLP mapping
- False automatic mappings
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
