MORC Family CW-Type Zinc Finger Protein 3

Preferred Label : MORC Family CW-Type Zinc Finger Protein 3;

NCIt synonyms : Nuclear Matrix Protein NXP2; Nuclear Matrix Protein 2; Zinc Finger CW-Type Coiled-Coil Domain Protein 3; Nuclear Matrix Protein NXP-2; NXP-2;

NCIt related terms : MJ ANTIGEN; MORC3; NXP2;

NCIt definition : MORC family CW-type zinc finger protein 3 (939 aa, 107 kDa) is encoded by the human MORC3 gene. This protein is involved in both RNA binding and nuclear matrix protein binding.;

Alternative definition : CDISC: An antigen encoded by the MORC3 gene that is involved in both RNA binding and nuclear matrix protein binding. It can be considered as an autoantigen and is commonly associated with the autoimmune diseases polymyositis and dermatomyositis.;

NCIt note : MORC family CW-type zinc finger protein 3 antibodies in patient sera may be a marker for cancer-associated dermatomyositis. (Arthritis & Rheumatism. 2013; 65: 2954-2962. doi: 10.1002/art.38093);

Details

Origin ID

C113142;

UMLS CUI

C3812252;

Automatic exact mappings (from CISMeF team)
- Morc family cw-type zinc finger protein 3 [OMIM gene]
- nuclear matrix protein 2 [MeSH concept]
- nuclear matrix protein 2 [MeSH Supplementary Concept]
OMIM relation
- Morc family cw-type zinc finger protein 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- MORC3 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nuclear Matrix [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Metal Binding Site [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Aging [NCIt concept]
- Ligand Binding [NCIt concept]
- Metal Ion Binding [NCIt concept]
- RNA Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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