" /> PI3K/mTOR Kinase Inhibitor VS-5584 - CISMeF





Preferred Label : PI3K/mTOR Kinase Inhibitor VS-5584;

NCIt synonyms : SB2343; SB 2343; VS5584; PI3K/mTOR Inhibitor VS-5584; SB-2343; VS 5584; 5-[8-Methyl-9-(1-Methylethyl)-2-(4-Morpholinyl)-9H-Purin-6-Yl]-2-Pyrimidinamine; 2-Pyrimidinamine, 5-[8-Methyl-9-(1-Methylethyl)-2-(4-Morpholinyl)-9H-Purin-6-Yl]-2-;

NCIt related terms : VS-5584;

NCIt definition : A potent and selective inhibitor of both phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling pathway, with potential antineoplastic activity. PI3K/mTOR kinase inhibitor VS-5584 inhibits mTOR kinase and all class I PI3K isoforms. Consequently, this disrupts phosphorylation of substrates downstream of PI3K and mTOR and may result in apoptosis and growth inhibition in susceptible tumor cells. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to chemotherapy and radiotherapy. mTOR is a serine/threonine kinase downstream of PI3K, which also has PI3K-independent activity. Consequently, this agent may potentially be more potent than an agent that inhibits either PI3K kinase or mTOR kinase.;

UNII : W71J4X250V;

CAS number : 1246560-33-7;

Molecule name : VS-5584;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
24/05/2025


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.