NCIt definition : A monoclonal antibody directed against the human epidermal growth factor receptor
3 (HER3; ERBB3) with potential antineoplastic activity. Anti-HER3 monoclonal antibody
GSK2849330 binds to HER3 and inhibits its activation. This may prevent HER3-mediated
signaling and inhibit HER3-dependent tumor cell proliferation and differentiation.
HER3, a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine
kinases, is frequently overexpressed in tumors and is associated with poor prognosis
and drug resistance; it has no active kinase domain but is activated through heterodimerization
with other members of the EGFR receptor family, such as HER2.;