Classical Glioblastoma

Preferred Label : Classical Glioblastoma;

NCIt definition : A molecular subtype of glioblastoma characterized by lack of p53 mutations, chromosome 7 amplifications or deletions, and high levels of EGFR amplification.;

Neoplastic status : Malignant;

Details

Origin ID

C111694;

UMLS CUI

C3827253;

Disease may have findings
- Headache [NCIt concept]
- Seizure [NCIt concept]
- Unfavorable Clinical Outcome [NCIt concept]
Has associated anatomic sites
- Central Nervous System [NCIt concept]
- Nervous System [NCIt concept]
Has cytogenetic abnormalities
- Gain of Chromosome 7 [NCIt concept]
- Loss of Chromosome 10 [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- NCIt Neoplasm Core Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Indolent Clinical Course [NCIt concept]
- Precise Histogenesis Unknown [NCIt concept]
disease_excludes_molecular_abnormality
- TP53 Gene Inactivation [NCIt concept]
disease_has_abnormal_cell
- Malignant Cell [NCIt concept]
- Neoplastic Astrocyte [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Glial Cell [NCIt concept]
- Neoplastic Neuroepithelial Cell [NCIt concept]
- Neoplastic Neuroepithelial Cell and Neoplastic Perineural Cell [NCIt concept]
- Poorly Differentiated Neoplastic Astrocyte [NCIt concept]
disease_has_finding
- Anaplastic Lesion [NCIt concept]
- Diffuse Pattern [NCIt concept]
- High Grade Lesion [NCIt concept]
- Infiltrative Growth Pattern [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Microvascular Proliferation [NCIt concept]
- Mitotic Activity [NCIt concept]
- Necrotic Change [NCIt concept]
- Nuclear Atypia [NCIt concept]
disease_has_grade
- Grade 4 [NCIt concept]
- High Grade [NCIt concept]
disease_has_molecular_abnormality
- EGFR Gene Amplification [NCIt concept]
disease_has_normal_cell_origin
- Astrocyte [NCIt concept]
- Glial Cell [NCIt concept]
- Neuroepithelial Cell [NCIt concept]
- Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System [NCIt concept]
disease_has_normal_tissue_origin
- Nerve Tissue, Neuroepithelial Tissue, and Nerve Sheaths [NCIt concept]
- Neuroepithelial Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Central Nervous System [NCIt concept]
disease_may_have_molecular_abnormality
- PTEN Gene Inactivation [NCIt concept]

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