Preferred Label : Anti-CD19-CAR FMC63-28Z Retroviral Vector-transduced Allogeneic T-lymphocytes;
NCIt synonyms : FMC63-28Z CAR-transduced Allogeneic T-lymphocytes; MSGV1-FMC63-28Z Anti-CD19 CAR-transduced Allogeneic T-lymphocytes;
NCIt definition : Allogeneic T-lymphocytes derived from peripheral blood mononuclear cells (PBMC) transduced
with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of
both the light and heavy chain variable regions of anti-CD19 monoclonal antibody FMC63,
coupled to the molecule CD28 and the signaling domain of the zeta chain of the T-cell
receptor (TCR) (FMC63-28Z), with potential immunomodulating and antineoplastic activities.
Upon transfusion, the anti-CD19-CAR FMC63-28Z retroviral vector-transduced allogeneic
T lymphocytes specifically recognize and kill CD19-expressing tumor cells. CD19 antigen
is a B-cell specific cell surface antigen, which is expressed in all B-cell lineage
malignancies and normal B-cells.;
NCI Metathesaurus CUI : CL453548;
Origin ID : C111041;
UMLS CUI : C3831522;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
