Staphylococcal Enterotoxin A

Preferred Label : Staphylococcal Enterotoxin A;

NCIt related terms : SEA;

NCIt definition : A bacterial enterotoxin with potential immunostimulatory activity. Staphylococcal enterotoxin A (SEA), a gram positive bacterial superantigen (SAg), is a potent stimulator of T-cell activation. SEA superantigen binds directly to class II major histocompatibility complex (MHC) molecules and to the V beta region of the T-cell receptor (TCR), leading to an amplified T-cell response. In response to SEA, both CD4 and CD8 cells proliferate, secrete cytokines, and demonstrate enhanced cytotoxic activity against a broad range of antigens. Vaccination with the SEA protein, administered by direct transfection into tumor cells, may elicit a non-specific cytotoxic T-cell (CTL) response and result in decreased tumor cell growth.;

Alternative definition : CDISC: The biotoxin Staphylococcal enterotoxin A.;

CAS number : 37337-57-8;

Details

Origin ID

C1083;

UMLS CUI

C0059385;

Currated CISMeF NLP mapping
- enterotoxin A, Staphylococcal [MeSH concept]
- enterotoxin A, Staphylococcal [MeSH Supplementary Concept]
False automatic mappings
- Sea (environment) [SNOMED CT concept]
- seas [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hazardous or Poisonous Substance [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- enterotoxin A, Staphylococcal [MeSH concept]
- enterotoxin A, Staphylococcal [MeSH Supplementary Concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CDISC SEND Chemical Challenge Agent Name Response Terminology [NCIt concept]
- CDISC SEND Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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