Dicycloplatin - CISMeF

Preferred Label : Dicycloplatin;

NCIt synonyms : DCP;

NCIt definition : A third-generation, supramolecular platinum-based compound composed of carboplatin linked, by a strong hydrogen bond, to 1,1-cyclobutane dicarboxylate (CBDCA), with potential antineoplastic activity. Although the exact mechanism of action has yet to be fully elucidated, dicycloplatin appears to have a mechanism of action similar to that of other platinum-based compounds, which involves both DNA binding and the formation of DNA crosslinks. This mechanism results in the induction of apoptosis and cell growth inhibition. Compared to carboplatin alone, dicycloplatin shows enhanced solubility and stability in aqueous solution and appears to have a more favorable toxicity profile.;

UNII : 0KC57I4UNB;

CAS number : 287402-09-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 287402-09-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Details

Origin ID

C107676;

UMLS CUI

C3815135;

Automatic exact mappings (from CISMeF team)
- Kartagener syndrome [MeSH Descriptor]
- Paraneoplastic neurologic syndrome [ORDO Disease]
- Primary ciliary dyskinesia [ORDO Disease]
- acarboxyprothrombin [MeSH Supplementary Concept]
- dynamic compression plate [Radlex concept]
- osteochondrodysplasias [MeSH Descriptor]
- paraneoplastic cerebellar degeneration [MeSH Descriptor]
CISMeF manual mappings
- diammine(1,1-cyclobutanedicarboxylate)platinum(II) [MeSH concept]
Currated CISMeF NLP mapping
- diammine(1,1-cyclobutanedicarboxylate)platinum(II) [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- diammine(1,1-cyclobutanedicarboxylate)platinum(II) [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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