C-Telopeptide of Type I Collagen Generated by Matrix Metalloproteinases

Preferred Label : C-Telopeptide of Type I Collagen Generated by Matrix Metalloproteinases;

NCIt synonyms : Cross-Linked C-Terminal Telopeptide of Type I Collagen Generated by Matrix Metalloproteinases; 1CTP; ICTP; MMP-Generated C-Terminal Telopeptide Type 1 Collagen; CTX-MMP;

NCIt definition : This polypeptide is comprised of the carboxy-terminal portions of fibrillar collagen, which are joined through trivalent crosslinks and released during the degradation of mature type I collagen by matrix metalloproteinases. Increased serum concentrations of these peptides are associated with pathologies that cause bone lysis, such as multiple myeloma, osteolytic metastases, and rheumatoid arthritis. Increased blood levels of these peptides are associated with renal insufficiency.;

NCIt note : Triple helical collagen is constructed from more than one gene product; thus, C-telopeptides arise from heterogeneous sources.;

Details

Origin ID

C107567;

UMLS CUI

C1173297;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
UMLS correspondences (same concept)
- C-terminal type I collagen telopeptide [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Collagen Gene [NCIt concept]
- Extracellular Matrix Protein Gene [NCIt concept]
- Structural Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Matrix [NCIt concept]
gene_product_has_chemical_classification
- Protein Fragment [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_physical_part_of
- Type I Collagen [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Adhesion Process [NCIt concept]
- Cell Growth [NCIt concept]
- Cell Movement [NCIt concept]
- Cell-Matrix Adhesion Process [NCIt concept]
- Morphogenesis [NCIt concept]
- Organogenesis [NCIt concept]
- Wound Repair [NCIt concept]

Keyword's position in hierarchy(ies) :

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