Preferred Label : CD19CAR-CD28zeta-4-1BB-expressing Allogeneic T Lymphocytes;
NCIt synonyms : Allogeneic CD19.CAR/28137zeta T-lymphocytes;
NCIt definition : Allogeneic T-lymphocytes transduced with a retroviral vector expressing a chimeric
antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable fragment)
coupled to the costimulatory signaling domain CD28, the signaling domain of 4-1BB
(CD137), and the zeta chain of the T-cell receptor (TCR), with potential immunomodulating
and antineoplastic activities. Upon transfusion, CD19CAR-CD28 zeta-4-1BB-expressing
allogeneic T lymphocytes directs the T-lymphocytes to and induces selective toxicity
in CD19-expressing tumor cells. CD28, a T-cell surface-associated co-stimulatory molecule,
is required for T-cell activation, proliferation, and survival. The 4-1BB co-stimulatory
molecule signaling domain enhances activation and signaling after recognition of CD19.
Furthermore, inclusion of the 4-1BB signaling domain may increase the antitumor activity
compared to the inclusion of the CD28 costimulatory domain and TCR zeta chain alone.
CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all
B-cell lineage malignancies.;
NCI Metathesaurus CUI : CL449496;
Origin ID : C107242;
UMLS CUI : C3831169;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
