NCIt definition : An orally bioavailable focal adhesion kinase (FAK) inhibitor with potential antineoplastic
activity. Upon administration, VS-4718 inhibits FAK, blocks fibronectin-stimulated
FAK autophosphorylation of Tyr397, and may prevent the integrin-mediated activation
of several downstream signal transduction pathways, including ERK, JNK/MAPK and PI3K/Akt.
This results in the reduction of the number of cancer stem cells (CSCs) and inhibits
tumor cell migration, proliferation and survival. The cytoplasmic tyrosine kinase
FAK is a signal transducer for integrins and is constitutively activated in various
tumor cell types; it is involved in tumor cell invasion, migration and proliferation
and plays a key role in the development, function and survival of CSCs.;
UNII : L2BD0MW4OL;
CAS number : 1061353-68-1; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1061353-68-1
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See also inter- (CISMeF)