Preferred Label : PBTL CD19CAR-28/CD137/zeta;
NCIt synonyms : CD19CAR/28137-bearing ATLs;
NCIt definition : Peripheral blood T-lymphocytes (PBTLs) transduced with a retroviral vector expressing
a chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable
fragment) coupled to the costimulatory signaling domain CD28, the signaling domain
of 4-1BB (CD137), and the zeta chain of the T-cell receptor (TCR), with potential
immunomodulating and antineoplastic activities. Upon transfusion, PBTL CD19CAR-28/CD137zeta
directs the T-lymphocytes to CD19-expressing tumor cells and induces selective toxicity
in CD19-expressing tumor cells. CD28, a T-cell surface-associated co-stimulatory molecule,
is required for full T-cell activation, proliferation, and survival. The 4-1BB co-stimulatory
molecule signaling domain enhances activation and signaling after recognition of CD19.
Furthermore, inclusion of the 4-1BB signaling domain may increase the antitumor activity
compared to the inclusion of the CD28 costimulatory domain and TCR zeta chain alone.
CD19 antigen is a B-cell specific cell surface antigen, which is expressed in all
B-cell lineage malignancies.;
Origin ID : C106429;
UMLS CUI : C3831433;
Semantic type(s)
- concept_is_in_subset
- has_target
