Preferred Label : Anti-CD27L Antibody-Drug Conjugate AMG 172;
NCIt related terms : AMG-172;
NCIt definition : An immunoconjugate consisting of a human IgG1 monoclonal antibody directed against
CD27L conjugated, via a non-cleavable linker, to the cytotoxic agent maytansinoid
DM1, with potential antineoplastic activity. The monoclonal antibody moiety of this
immunoconjugate binds to CD27L on tumor cell surfaces. After internalization, the
DM1 moiety binds to tubulin, thereby disrupting microtubule assembly/disassembly dynamics
and inhibiting both cell division and proliferation of cancer cells that express CD27L.
CD27L, a type II transmembrane protein and member of the tumor necrosis factor family,
is a co-stimulatory molecule constitutively expressed on a subset of activated T-cells,
B-cells, and dendritic cells, which is overexpressed in certain tumor cell types.;
UNII : B6M586T6SD;
Molecule name : AMG-172; AMG 172;
NCI Metathesaurus CUI : CL433957;
Origin ID : C106266;
UMLS CUI : C3827165;
Semantic type(s)
- concept_is_in_subset
- has_target
