NCIt definition : An inhibitor of CXC chemokine receptor 4 (CXCR4), with potential antineoplastic activity.
Upon subcutaneous administration, CXCR4 inhibitor LY2510924 binds to the chemokine
receptor CXCR4, thereby preventing CXCR4 binding to its ligand, stromal derived factor-1
(SDF-1), and subsequent receptor activation. This may result in decreased tumor cell
proliferation and migration. CXCR4, a chemokine receptor belonging to the G protein-coupled
receptor (GPCR) gene family, plays an important role in chemotaxis and angiogenesis
and is upregulated in several tumor cell types.;