Preferred Label : Sofituzumab Vedotin;
NCIt definition : An antibody drug conjugate (ADC) consisting of a humanized IgG1 monoclonal antibody
targeting the MUC16 protein (CA-125) conjugated to, via a cleavable linker, the antimicrotubulin
agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. The
monoclonal antibody moiety of sofituzumab vedotin selectively binds to MUC16. After
internalization of the drug conjugate and proteolytic cleavage of the linker, MMAE
binds to tubulin and inhibits its polymerization, which results in G2/M-phase growth
arrest and tumor cell apoptosis. MUC16, a transmembrane protein, is overexpressed
on the cell surface of more than 80 percent of ovarian cancer cells but not on healthy
cells.;
UNII : 2X3CKG601L;
CAS number : 1418200-58-4; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1418200-58-4
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G-SRS /a ;
Molecule name : DMUC5754A;
NCI Metathesaurus CUI : CL433830;
Origin ID : C106119;
UMLS CUI : C4688397;
Semantic type(s)
- concept_is_in_subset
- has_target
