Preferred Label : Microtubule-Associated Proteins 1A/1B Light Chain 3-II;
NCIt synonyms : MAP1LC3-II; LC3-II; LC3 II;
NCIt definition : Microtubule-associated proteins 1A/1B light chain 3-II proteins (LC3-II) are products
of the autophagy-dependent processing of microtubule-associated proteins 1A/1B light
chain 3 family proteins (LC3). During autophagy, LC3 proteins are cleaved by cysteine
protease ATG4B to form LC3-I intermediates which are located in the cytoplasm. As
autophagy progresses, LC3-I proteins interact with both ubiquitin-like modifier-activating
enzyme ATG7 and ubiquitin-like-conjugating enzyme ATG3. These interactions result
in further proteolysis and the conjugation of a phospholipid anchor to form the membrane
localized LC3-II.;
Origin ID : C105644;
UMLS CUI : C3642279;
Semantic type(s)
- concept_is_in_subset
