Preferred Label : Denintuzumab Mafodotin;
NCIt synonyms : ADC SGN-19A; Immunoglobulin G1-kappa Auristatin F Conjugate, Anti-(homosapiens CD19 (B Lymphocyte
Surface Antigen B4, leu-12)), Humanized Monoclonal Antibody;
NCIt definition : An immunoconjugate consisting of an anti-CD19 monoclonal antibody conjugated to the
auristatin derivative monomethyl auristatin F (MMAF), with potential antineoplastic
activity. Upon administration of denintuzumab mafodotin, the antibody moiety targets
the cell surface antigen CD19, found on a number of B-cell-derived cancers. Upon antibody/antigen
binding and internalization, the immunoconjugate releases MMAF, which binds to tubulin
and inhibits its polymerization. Inhibition of tubulin polymerization may result in
G2/M phase arrest and tumor cell apoptosis. This causes inhibition of cell growth
of CD19-expressing tumor cells. CD19, a B-cell antigen, is overexpressed by a variety
of different cancer cell types.;
UNII : H5324S1M7H;
CAS number : 1399672-02-6;
Molecule name : SGN-CD19A; SGN-19A; SGN CD19A;
NCI Metathesaurus CUI : CL446112;
Codes from synonyms : 153;
Origin ID : C105150;
UMLS CUI : C4086238;
Semantic type(s)
- concept_is_in_subset
- has_target
