Prostaglandin E Synthase 2

Preferred Label : Prostaglandin E Synthase 2;

NCIt synonyms : Microsomal Prostaglandin E Synthase 2; Membrane-Associated Prostaglandin E Synthase 2; PTGES2; GATE-Binding Factor 1; EC 5.3.99.3; mPGES-2; Gamma-Interferon-Activated Transcriptional Element-Binding Factor 1;

NCIt definition : Prostaglandin E synthase 2 (377 aa, 42 kDa) is encoded by the human PTGES2 gene. This protein plays a role in both the synthesis of prostaglandin E2 and transcriptional activation.;

NCIt note : Prostaglandin E synthase 2 activates the transcription of gamma-IFN-activated transcriptional element-dependent genes by an unknown mechanism. (J Biol Chem. 2002; 277:30253-63.);

PubMed : 12050152;

Details

Origin ID

C105116;

UMLS CUI

C4082991;

Currated CISMeF NLP mapping
- prostaglandin E synthase 2 [MeSH concept]
OMIM relation
- Prostaglandin e synthase 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Isomerase Gene [NCIt concept]
- PTGES2 Gene [NCIt concept]
gene_product_has_chemical_classification
- Microsomal Prostaglandin E Synthase Family [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Arachidonic Acid Metabolism Pathway [NCIt concept]
- Interferon-Gamma Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Prostaglandin Production [NCIt concept]
- Transcriptional Regulation [NCIt concept]

Keyword's position in hierarchy(ies) :

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