C-1-Tetrahydrofolate Synthase, Cytoplasmic

Preferred Label : C-1-Tetrahydrofolate Synthase, Cytoplasmic;

NCIt synonyms : 5,10-Methylenetetrahydrofolate Dehydrogenase, 5,10-Methylenetetrahydrofolate Cyclohydrolase, 10-Formyltetrahydrofolate Synthetase; C1-THF Synthase; MTHFD1; Cytoplasmic C-1-Tetrahydrofolate Synthase;

NCIt definition : C-1-tetrahydrofolate synthase, cytoplasmic (935 aa, 102 kDa) is encoded by the human MTHFD1 gene. This protein plays a role in folic acid metabolism.;

NCIt note : C-1-tetrahydrofolate synthase, cytoplasmic has the following activities: methylenetetrahydrofolate dehydrogenase (EC 1.5.1.5), methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) and formyltetrahydrofolate synthetase (EC 6.3.4.3). (UniProt);

Details

Origin ID

C104923;

UMLS CUI

C3539843;

Automatic exact mappings (from CISMeF team)
- Methylenetetrahydrofolate dehydrogenase 1 [OMIM gene]
- formyl-methenyl-methylenetetrahydrofolate synthetase [MeSH Supplementary Concept]
- methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 [ORDO Gene]
OMIM relation
- Methylenetetrahydrofolate dehydrogenase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Ligase Gene [NCIt concept]
- MTHFD1 Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- One Carbon Pool by Folate Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Folic Acid Metabolic Process [NCIt concept]
- Hydrolysis [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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