Preferred Label : IGF-1R Inhibitor PL225B;
NCIt definition : An orally bioavailable inhibitor of the insulin-like growth factor 1 receptor (IGF-1R)
with potential antineoplastic activity. IGF-1R inhibitor PL225B selectively binds
to and inhibits the activities of IGF-1R, which may result in both the inhibition
of tumor cell proliferation and the induction of tumor cell apoptosis in IGF-1R-overexpressing
tumor cells. IGF-1R, a receptor tyrosine kinase overexpressed in a variety of human
cancers, plays a significant role in the stimulation of cellular proliferation, oncogenic
transformation, and suppression of apoptosis.;
Molecule name : PL225B;
NCI Metathesaurus CUI : CL445817;
Origin ID : C104746;
UMLS CUI : C3641864;
Semantic type(s)
- concept_is_in_subset
- has_target
