" /> Ulixertinib - CISMeF





Preferred Label : Ulixertinib;

NCIt synonyms : 1H-Pyrrole-2-carboxamide, 4-(5-chloro-2-((1-methylethyl)amino)-4-pyridinyl)-N-((1S)-1-(3-chlorophenyl)-2-hydroxyethyl)-;

NCIt definition : An orally available inhibitor of extracellular signal-regulated kinase (ERK) 1 and 2, with potential antineoplastic activity. Upon oral administration, ulixertinib inhibits both ERK 1 and 2, thereby preventing the activation of ERK-mediated signal transduction pathways. This results in the inhibition of ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is often upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival.;

UNII : 16ZDH50O1U;

InChIKey : KSERXGMCDHOLSS-LJQANCHMSA-N;

CAS number : 869886-67-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 869886-67-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : BVD-523; VRT752271;

NCI Metathesaurus CUI : CL445815;

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12/05/2024


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