Preferred Label : Technetium Tc 99 Hydrazinonicotinamide-Tricine-linked Interleukin-2;
NCIt synonyms : 99mTc-HYNIC-IL2;
NCIt definition : A radioconjugate composed of the cytokine interleukin-2 (IL-2) conjugated to the bifunctional
chelating agent succinimidyl-6-hydrazinopyridine-3-carboxylate (HYNIC-NHS) and co-ligand
tricine and labeled with the radioisotope technetium Tc 99m (99mTc-HYNIC-IL2), that
can potentially be used as a diagnostic agent to detect tumor inflammation. Upon intravenous
administration, IL-2 selectively binds to the IL-2 receptor (IL-2R) expressed on tumor
infiltrating lymphocytes (TILs); upon internalization, the Tc99m moiety can be visualized
using radioimaging, which allows the quantification of TILs expressing IL-2R. This
agent detects tumor enlargement due to invasion by TILs and not tumor progression.;
NCI Metathesaurus CUI : CL445806;
Origin ID : C104731;
UMLS CUI : C3641855;
Semantic type(s)
- concept_is_in_subset
- has_target
