Peptidyl-Prolyl Cis-Trans Isomerase FKBP8

Preferred Label : Peptidyl-Prolyl Cis-Trans Isomerase FKBP8;

NCIt synonyms : Rotamase; 38 kDa FK506-Binding Protein; EC 5.2.1.8; FK506-Binding Protein 8; FKBP8;

NCIt definition : Peptidyl-prolyl cis-trans isomerase FKBP8 (412 aa, 45 kDa) is encoded by the human FKBP8 gene. This protein is involved in immunoregulation, protein folding, and protein trafficking and may play a role in neurons associated with memory.;

NCIt note : Unlike other members of the family, peptidyl-prolyl cis-trans isomerase FKBP8 seems to lack PPIase/rotamase activity.;

Details

Origin ID

C104390;

UMLS CUI

C1174216;

OMIM relation
- Fk506-binding protein 8 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- FKBP8 protein, human [MeSH concept]
- FKBP8 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- FKBP8 Gene [NCIt concept]
- Isomerase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
- Tetratricopeptide Repeat [NCIt concept]

Keyword's position in hierarchy(ies) :

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