Preferred Label : p53/HDM2 Interaction Inhibitor CGM097;
NCIt synonyms : HDM2/p53 Inhibitor CGM097;
NCIt related terms : CGM-097;
NCIt definition : An orally bioavailable HDM2 (human homolog of double minute 2) antagonist with potential
antineoplastic activity. Upon oral administration, p53/HDM2 interaction inhibitor
CGM097 inhibits the binding of the HDM2 protein to the transcriptional activation
domain of the tumor suppressor protein p53. By preventing this HDM2-p53 interaction,
the proteasome-mediated enzymatic degradation of p53 is inhibited, which may result
in the restoration of p53 signaling and, thus, the p53-mediated induction of tumor
cell apoptosis. HDM2, a zinc finger nuclear phosphoprotein, is a negative regulator
of the p53 pathway, often overexpressed in cancer cells and has been implicated in
cancer cell proliferation and survival.;
UNII : 4UF6MSL0ZH;
CAS number : 1313363-54-0;
Molecule name : CGM097;
Origin ID : C104280;
UMLS CUI : C3641742;
Semantic type(s)
- concept_is_in_subset
- has_target
