Glycogen Synthase Kinase 3

Preferred Label : Glycogen Synthase Kinase 3;

NCIt synonyms : GSK-3; Glycogen Synthase Kinase- 3; GSK3;

NCIt definition : A family of serine/threonine protein kinases that is involved in intracellular signaling, cellular proliferation, cell migration, inflammation and immune responses, glucose regulation, and apoptosis.;

NCIt note : There are 2 known mammalian glycogen synthase kinase-3 genes, GSK3A and GSK3B.;

Details

Origin ID

C104099;

UMLS CUI

C0244989;

Automatic exact mappings (from CISMeF team)
- glycogen synthase kinase 3 [MeSH Descriptor]
- glycogen synthase kinase 3 [MeSH concept]
Biochemical function of gene products
- Glycogen Synthase Kinase-3 Alpha [NCIt concept]
- Glycogen Synthase Kinase-3 Beta [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- glycogen synthase kinase 3 [MeSH concept]
- glycogen synthase kinase 3 [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Kinase Family Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
gene_product_has_biochemical_function
- Phosphotransferase [NCIt concept]
- Serine/Threonine Protein Kinase [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Death Process [NCIt concept]
- Cell Motility [NCIt concept]
- Cell Proliferation [NCIt concept]
- Glycogenesis Induction [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Elraglusib [NCIt concept]
- GSK-3 Inhibitor LY2090314 [NCIt concept]

Keyword's position in hierarchy(ies) :

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