Preferred Label : Telapristone Acetate;
NCIt synonyms : Proellex; Progenta; (8S,11R,13S,14S,17R)-11-(4-(Dimethylamino)phenyl)-17-(2-methoxyacetyl)-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl
Acetate;
NCIt definition : The acetate form of the 21-substituted-19-nor-progestin telapristone, an orally available
selective progesterone receptor modulator (SPRM), with potential anti-progesterone
and antineoplastic activities. Upon oral administration, CDB-4124 competitively binds
to the progesterone receptor (PR) in progesterone-responsive tissue and inhibits PR-mediated
gene expression. This interferes with progesterone activity in the reproductive system.
As a result, this agent may suppress ovulation and inhibit proliferation of endometrial
tissue. Also, this agent may prevent cell growth and induce apoptosis in estrogen
receptor (ER) and PR-positive breast cancer cells through a reduction in progesterone
levels, ER downregulation and a suppression of the expression of cyclin-dependent
kinases (CDK) 2 and 4, ultimately leading to G1/S cell cycle arrest. Unlike some other
SPRMs, this agent does not exert any estrogenic, androgenic, anti-estrogenic, and
anti-androgenic activities.;
UNII : 1K9EYK92PQ;
InChIKey : JVBGZFRPTRKSBB-MJBQOYBXSA-N;
CAS number : 198414-31-2;
Molecule name : CDB-4124;
Origin ID : C104055;
UMLS CUI : C3501648;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
