Preferred Label : Recombinant Human Hsp110-gp100 Chaperone Complex Vaccine;
NCIt definition : A recombinant chaperone-peptide complex-based vaccine composed of a complex between
heat shock protein hsp110 and the human melanoma-associated antigen gp100, with potential
antineoplastic activity. Upon vaccination, recombinant hsp110-gp100 chaperone complex
activates the immune system to exert a cytotoxic T cell immune response and antigen-specific
interferon-gamma production against gp100-overexpressing cancer cells. Gp100, is overexpressed
in a variety of cancer cell types. Hsp110, binds to and chaperones full-length proteins
during heat shock; as an immunoadjuvant it is able to enhance an immune response against
antigen(s) and stimulate T-lymphocyte activation.;
NCI Metathesaurus CUI : CL438310;
Origin ID : C103830;
UMLS CUI : C3641632;
Semantic type(s)
- concept_is_in_subset
- has_target
