Preferred Label : Acalisib;
NCIt synonyms : 6-Fluoro-3-phenyl-2-((1S)-1-(7H-purin-6-ylamino)ethyl)quinazolin-4(3H)-one;
NCIt definition : An inhibitor of the beta and delta isoforms of the 110 kDa catalytic subunit of class
IA phosphoinositide-3 kinases (PI3K) with potential immunomodulating and antineoplastic
activities. Acalisib inhibits the activity of PI3K, thereby preventing the production
of the second messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3), which decreases
tumor cell proliferation and induces cell death. PI3K-mediated signaling is often
dysregulated in cancer cells; the targeted inhibition of PI3K is designed to preserve
PI3K signaling in normal, non-neoplastic cells.;
UNII : OVW60IDW1D;
InChIKey : DOCINCLJNAXZQF-LBPRGKRZSA-N;
CAS number : 870281-34-8;
Molecule name : GS-9820; CAL-120;
NCI Metathesaurus CUI : CL438128;
Origin ID : C103277;
UMLS CUI : C4682389;
Semantic type(s)
- concept_is_in_subset
- has_target
