Diammonium Glycyrrhizinate

Preferred Label : Diammonium Glycyrrhizinate;

NCIt synonyms : 18beta-Glycyrrhizic Acid Diammoniumsalt; alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-Glucopyranuronosyl-, Diammonium Salt (9CI);

NCIt definition : The diammonium salt of glycyrrhizin and the active constituent in the traditional Chinese medicinal herb Glycyrrhiza uralensis (Chinese liquorice or Gan-Cao) with anti-inflammatory, antioxidant and hepatoprotective properties. Diammonium glycyrrhizinate (DG) is slowly metabolized within the cells into glycyrrhetic acid, which inhibits enzymes that control cortisol metabolism and contributes to this agent's anti-inflammatory effect. Although the exact mechanism of action remains to be fully elucidated, DG may prevent or reduce hepatotoxicity via the scavenging of free radicals. This agent also upregulates the expression of transcription coactivator PGC-1alpha and modulates hepatic enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), superoxide dismutase and glutathion peroxidase.;

UNII : A9ZZD585U6;

CAS number : 79165-06-3;

Chemical formula : C42H62O16.2H3N;

Details

Origin ID

C102865;

UMLS CUI

C1956193;

Automatic exact mappings (from CISMeF team)
- diammonium glycyrrhizinate [MeSH concept]
- glycyrrhizic acid [MeSH Descriptor]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- diammonium glycyrrhizinate [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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