Efbemalenograstim alfa

Preferred Label : Efbemalenograstim alfa;

NCIt synonyms : Recombinant Dimeric G-CSF Fusion Protein F627; Rh G-CSF Fc Fusion Protein F-627;

NCIt definition : A recombinant dimeric fusion peptide of the human granulocyte colony-stimulating factor (G-CSF; filgrastim), with immunomodulating and hematopoietic activities. Efbemalenograstim alfa binds to the cell surface G-CSF receptors (G-CSFRs) inducing receptor dimerization and activation of signaling cascades such as the Jak-STAT and mitogen-activated protein kinase pathways. This stimulates neutrophil progenitor proliferation and differentiation. Compared to other preparations of monomer recombinant G-CSF, dimeric filgrastim may allow for stronger activation of G-CSFRs and a faster myeloid precursor response thus enhancing neutrophil recovery upon myelosuppressive therapy.;

UNII : 5UPW5HJW3O;

CAS number : 2200269-79-8;

Molecule name : F-627;

NCI Metathesaurus CUI : CL437135;

Details

Origin ID

C102854;

UMLS CUI

C5400023;

Currated CISMeF NLP mapping
- Efbemalenograstim alfa [SMS substance]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- efbemalenograstim alfa [ATC Code]
Validated automatic mappings to BTNT
- efbemalenograstim alfa [ATC Code]
chemical_or_drug_affects_cell_type_or_tissue
- Hematopoietic Stem Cell [NCIt concept]
chemical_or_drug_affects_gene_product
- GM-CSF Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Cell Differentiation [NCIt concept]
- Receptor Activation Process [NCIt concept]
- Stimulation of Cell Proliferation [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Granulocyte Colony-Stimulating Factor Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

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