Preferred Label : Rivipansel;

NCIt definition : A synthetic, glycomimetic molecule and pan-selectin antagonist, with potential use in a vaso-occlusive crisis. Upon administration, rivipansel prevents the interaction between leukocytes and the endothelium and may prevent cell activation and adhesion. By preventing selectin-mediated cell adhesion in sickle cell anemia, this agent may inhibit red blood cell-white blood cell interactions, normalize blood flow and reduce inflammation and vascular occlusive pain. GMI-1070 has the strongest antagonistic activity towards E-selectin but a sulfate-binding domain allows for interactions with P- and L-selectins. Selectins, containing lectin- and EGF-like domains, are a family of cell adhesion molecules implicated in inflammatory processes and cancer.;

UNII : 4B115V09LB;

InChIKey : VXBNTHRZPJLRSS-PTCSXESPSA-N;

CAS number : 927881-99-0;

Molecule name : GMI-1070; PF-06460031;

NCI Metathesaurus CUI : CL777451;

Details


Main resources

You can consult :


http://beh.santepubliquefrance.fr/beh/2023/18/2023_18_3.html
2023
France
journal article
Rivipansel
Vorozole
COVID-19 Infection
Autoimmune Lymphoproliferative Syndrome
Liver Specific Alkaline Phosphatase Measurement
COVID-19
unilateral
Burden
ribs
residential facilities

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