Rivipansel - CISMeF

Preferred Label : Rivipansel;

NCIt definition : A synthetic, glycomimetic molecule and pan-selectin antagonist, with potential use in a vaso-occlusive crisis. Upon administration, rivipansel prevents the interaction between leukocytes and the endothelium and may prevent cell activation and adhesion. By preventing selectin-mediated cell adhesion in sickle cell anemia, this agent may inhibit red blood cell-white blood cell interactions, normalize blood flow and reduce inflammation and vascular occlusive pain. GMI-1070 has the strongest antagonistic activity towards E-selectin but a sulfate-binding domain allows for interactions with P- and L-selectins. Selectins, containing lectin- and EGF-like domains, are a family of cell adhesion molecules implicated in inflammatory processes and cancer.;

UNII : 4B115V09LB;

InChIKey : VXBNTHRZPJLRSS-PTCSXESPSA-N;

CAS number : 927881-99-0;

Molecule name : GMI-1070; PF-06460031;

NCI Metathesaurus CUI : CL777451;

Details

Origin ID

C102786;

UMLS CUI

C4519206;

Automatic exact mappings (from CISMeF team)
- rivipansel [MeSH concept]
- rivipansel [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GMI-1070 [MeSH concept]
- rivipansel [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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