Preferred Label : Recombinant Human MUC1-Oxidized Polymannose-pulsed Autologous Dendritic Cell Vaccine;
NCIt definition : A cancer vaccine containing autologous dendritic cells pulsed with a fusion product
of an epitope of human tumor-associated epithelial mucin 1 (MUC1) antigen and the
vaccine adjuvant mannan (oxidized mannose), with potential antineoplastic activity.
When the modified dendritic cells are returned to the patient, they may stimulate
the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor
cells positive for the MUC1 antigen, resulting in tumor cell lysis. Addition of manna
in this vaccine, enhances immune recognition. MUC1 antigen, a high-molecular-weight
transmembrane glycoprotein, is overexpressed on many tumor cells.;
Origin ID : C102782;
UMLS CUI : C3640942;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
