Preferred Label : Selinexor;
NCIt synonyms : Selective Inhibitor of Nuclear Export KPT-330; SINE KPT-330; CRM1 Nuclear Export Inhibitor KPT-330; 2-Propenoic Acid, 3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-, 2-(2-Pyrazinyl)hydrazide,
(2Z)-;
NCIt definition : An orally available, small molecule inhibitor of CRM1 (chromosome region maintenance
1 protein, exportin 1 or XPO1), with potential antineoplastic activity. Selinexor
modifies the essential CRM1-cargo binding residue cysteine-528, thereby irreversibly
inactivates CRM1-mediated nuclear export of cargo proteins such as tumor suppressor
proteins (TSPs), including p53, p21, BRCA1/2, pRB, FOXO, and other growth regulatory
proteins. As a result, this agent, via the approach of selective inhibition of nuclear
export (SINE), restores endogenous tumor suppressing processes to selectively eliminate
tumor cells while sparing normal cells. CRM1, the major export factor for proteins
from the nucleus to the cytoplasm, is overexpressed in a variety of cancer cell types.;
UNII : 31TZ62FO8F;
InChIKey : DEVSOMFAQLZNKR-RJRFIUFISA-N;
CAS number : 1393477-72-9;
Drug name : Xpovio; Nexpovio;
Molecule name : KPT-330; ATG-010; KPT 330;
Codes from synonyms : 461;
Origin ID : C102546;
UMLS CUI : C3852671;
Currated CISMeF NLP mapping
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
- has_target
- is_component_of_chemotherapy_regimen
