" /> Anti-ErbB3 Monoclonal Antibody AV-203 - CISMeF





Preferred Label : Anti-ErbB3 Monoclonal Antibody AV-203;

NCIt synonyms : Anti-ErbB3 MoAb AV-203;

NCIt related terms : AV-203;

NCIt definition : A humanized monoclonal antibody (MoAb) directed against the human receptor tyrosine-protein kinase ErbB-3 (HER3) with potential antineoplastic activity. Anti-ErbB3 MoAb AV-203 binds to and inhibits both ligand neuregulin-1 (NRG-1)-dependent and ligand-independent ErbB3 activation, which may result in inhibition of ErbB3-dependent PI3K/Akt signaling and may lead to inhibition of cellular proliferation and differentiation. ErbB3, a member of the epidermal growth factor receptor (EGFR) family, is frequently overexpressed in solid tumors and its overexpression generally correlates with poor prognosis and tumor resistance; it has no active kinase domain itself but is activated through heterodimerization with other members of the EGFR receptor family that do.;

UNII : 841P9W25WA;

CAS number : 1353581-77-7; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1353581-77-7 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AV-203; CAN-017; AV 203;

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15/05/2024


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