Bisantrene - CISMeF

Preferred Label : Bisantrene;

NCIt synonyms : 9,10-Anthracenedicarboxaldehyde Bis(2-imidazolin-2-yl)hydrazone; 9,10-Anthracenedicarboxakdehyde Bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone];

NCIt definition : An anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication. This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. (NCI04);

UNII : 39C34M111K;

InChIKey : NJSMWLQOCQIOPE-OCHFTUDZSA-N;

CAS number : 78186-34-2;

Chemical formula : C22H22N8;

Details

Origin ID

C1019;

UMLS CUI

C0053776;

Currated CISMeF NLP mapping
- bisantrene [MeSH concept]
- bisantrene [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- bisantrene [MeSH concept]
- bisantrene [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Bisantrene Hydrochloride [NCIt concept]
is_free_acid_or_base_form_of
- Bisantrene Hydrochloride [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients