Serine Protease Hepsin

Preferred Label : Serine Protease Hepsin;

NCIt synonyms : EC 3.4.21.106; TMPRSS1; Transmembrane Protease Serine 1; HPN;

NCIt definition : Serine protease hepsin (417 aa, 45 kDa) is encoded by the human HPN gene. This protein is involved in proteolysis.;

NCIt note : Serine protease hepsin is cleaved to an inactive chain and a catalytically active chain. (UniProt);

NCI Metathesaurus CUI : CL933375;

Details

Origin ID

C101720;

UMLS CUI

C4705796;

OMIM relation
- Hepsin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- HPN protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- HPN Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membrane of the Endoplasmic Reticulum [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Scavenger Receptor Cysteine-Rich Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Growth Regulation [NCIt concept]
- Hydrolysis [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Negative Regulation of Apoptosis [NCIt concept]
- Proteolysis [NCIt concept]
- Regulation of Cell Size [NCIt concept]

Keyword's position in hierarchy(ies) :

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