Preferred Label : Indium In 111 Anti-CD45 Monoclonal Antibody BC8;
NCIt synonyms : monoclonal antibody BC8, indium In 111; Indium In 111 Monoclonal Antibody BC8; In 111 Monoclonal Antibody BC8; In 111 MOAB BC8;
NCIt definition : A radioimmunoconjugate containing the murine IgG1 anti-CD45 monoclonal antibody (MoAb)
BC8 labeled with the gamma-emitting isotope indium 111 (In 111), with potential radioimaging
application. Upon administration, indium In 111 anti-CD45 monoclonal antibody BC8
binds to CD45 antigen, a receptor protein tyrosine phosphatase expressed on the surface
of most of the normal and malignant hematopoietic cells. After binding and internalization
by CD45-expressing tumor cells, radioactive In 111 allows for the detection of BC8
distribution and tumor localization using gamma scintigraphy.;
NCI Metathesaurus CUI : CL435779;
Origin ID : C101522;
UMLS CUI : C3640128;
Semantic type(s)
- concept_is_in_subset
- has_target
