Preferred Label : CD19CAR-CD3zeta-4-1BB-expressing Allogeneic T-lymphocyte Cells;
NCIt synonyms : CART-19 Cells;
NCIt definition : Allogeneic T-lymphocytes transduced with a modified lentiviral vector expressing a
chimeric antigen receptor (CAR) consisting of an anti-CD19 scFv (single chain variable
fragment) and the zeta chain of the TCR/CD3 complex (CD3-zeta), coupled to the signaling
domain of 4-1BB (CD137), with potential immunomodulating and antineoplastic activities.
Upon transfusion, CD19CAR-CD3zeta-4-1BB-expressing allogeneic T-lymphocyte cells direct
the T-lymphocytes to CD19-expressing tumor cells, thereby inducing a selective toxicity
in CD19-expressing tumor cells. The 4-1BB co-stimulatory molecule signaling domain
enhances activation and signaling after recognition of CD19 and the inclusion of this
signaling domain may increase the antitumor activity compared to the inclusion of
the CD3-zeta chain alone. CD19 antigen is a B-cell specific cell surface antigen expressed
in all B-cell lineage malignancies.;
NCI Metathesaurus CUI : CL435506;
Origin ID : C101258;
UMLS CUI : C3640056;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
