Preferred Label : IGF-1R Antisense Oligodeoxynucleotide-treated Autologous Glioma Cells IGV-001;
NCIt synonyms : IGF-1R/AS ODN-treated Autologous Glioma Cells IGV-001;
NCIt definition : A preparation of irradiated autologous glioma cells treated ex vivo with IMV-001,
an antisense oligodeoxynucleotide of insulin-like growth factor receptor 1 (IGF-1R/AS
ODN), and encapsulated within bio-diffusion chambers, with potential antineoplastic
activity. The IGF-1R/AS ODN IMV-001-treated autologous glioma cells IGV-001 are encapsulated
within implantable and removable bio-diffusion chambers with additional IMV-001, irradiated,
and implanted into the patient. The IGF-1R/AS ODN binds to IGF-1R mRNA in glioma cells,
and shuts down the translation of IGF-1R in the glioma cells. Downregulation of IGF-1R,
in addition to irradiation, induces apoptosis and causes the release of exosomes,
which contain tumor-associated antigens (TAAs). The diffusion of exosomes together
with the additional IMV-001 from the bio-diffusion chambers may activate the patient's
immune system and mount a cytotoxic T-lymphocyte (CTL) response against cells expressing
these TAAs. IGF-1R, a receptor tyrosine kinase, is overexpressed in a variety of tumor
cell types and is essential for tumor cell growth, transformation and survival.;
Molecule name : IGV 001; IGV-001;
NCI Metathesaurus CUI : CL435505;
Origin ID : C101257;
UMLS CUI : C5557440;
Semantic type(s)
- Cell [UMLS semantic type]
- UMLS correspondences (same concept)
- IGV-001 [MeSH Supplementary Concept]
- concept_is_in_subset
- has_target
