CBFB/MYH11 Fusion Protein

Preferred Label : CBFB/MYH11 Fusion Protein;

NCIt synonyms : CBFbeta-MYH11 Fusion Protein; CBFbeta-SMMHC Fusion Protein; CBFb-MYH11 Fusion Protein; Core-Binding Factor Subunit Beta/Myosin-11 Fusion Protein; CBFbeta/SMMHC Fusion Protein; Core-Binding Factor Subunit Beta::Myosin-11 Fusion Protein; CBFB::MYH11 Fusion Protein;

NCIt definition : A fusion protein encoded by the CBFB/MYH11 fusion gene. This protein is comprised of most of the core-binding factor subunit beta fused to the C-terminal dimerization domain of myosin-11.;

NCIt note : The CBFB/MYH11 fusion protein appears to act as a dominant-negative for the transcriptional activation activity mediated by the intact core-binding factor subunit beta protein.;

Details

Origin ID

C101052;

UMLS CUI

C0381246;

Automatic exact mappings (from CISMeF team)
- CBFbeta-MYH11 fusion protein [MeSH Supplementary Concept]
- CBFbeta-MYH11 fusion protein [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CBFbeta-MYH11 fusion protein [MeSH Supplementary Concept]
- CBFbeta-MYH11 fusion protein [MeSH concept]
gene_encodes_gene_product
- CBFB/MYH11 Fusion Gene [NCIt concept]
- Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Transcriptional Repression [NCIt concept]
related_to_genetic_biomarker
- CBFB Gene [NCIt concept]
- MYH11 Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

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