Preferred Label : pitolisant;
MeSH note : functions as both inverse agonist and antagonist of histamine H3 receptors; structure
in first source;
CISMeF synonym : BF2.649;
MeSH synonym : 1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine;
MeSH hyponym : tiprolisant;
Is substance : O;
UNII : 4BC83L4PIY;
InChIKey : NNACHAUCXXVJSP-UHFFFAOYSA-N;
Origin ID : C516975;
UMLS CUI : C3529928;
ATC code(s)
Currated CISMeF NLP mapping
MeSH indexing information
MeSH term(s) associated for indexing
Record concept(s)
See also inter- (CISMeF)
Semantic type(s)
UMLS correspondences (same concept)
Validated automatic mappings to BTNT
https://www.has-sante.fr/jcms/p_3456303/fr/wakix-pitolisant-narcolepsie
2023
false
false
false
France
pitolisant
treatment outcome
insurance, health, reimbursement
adolescent
child
administration, oral
Narcolepsy type 1
Narcolepsy type 2
evaluation of the transparency committee
pitolisant
narcolepsy
---
https://www.has-sante.fr/jcms/p_3315446/fr/ozawade-pitolisant
2022
false
false
false
France
administration, oral
insurance, health, reimbursement
treatment outcome
sleep apnea, obstructive
sleep arousal disorders
Excessive Daytime Sleepiness
pitolisant
evaluation of the transparency committee
pitolisant
---
https://ansm.sante.fr/tableau-atu-rtu/ozawade-4-5-mg-18-mg-comprimes-pellicules
2021
false
false
false
France
French
guidelines for drug use
administration, oral
pitolisant
pitolisant
Excessive Daytime Sleepiness
sleep apnea, obstructive
adult
disorders of excessive somnolence
piperidines
piperidines
---
https://www.ema.europa.eu/en/medicines/human/EPAR/ozawade
2021
false
false
false
Netherlands
French
English
treatment outcome
syndication feed
summary of product characteristics
package leaflet
drug evaluation
drug approval
europe
pitolisant
pitolisant
adult
sleep apnea, obstructive
administration, oral
pitolisant
histamine h3 antagonists
histamine h3 antagonists
Product containing precisely pitolisant (as pitolisant hydrochloride) 4.45 milligram/1
each conventional release oral tablet (clinical drug)
Product containing precisely pitolisant (as pitolisant hydrochloride) 17.8 milligram/1
each conventional release oral tablet (clinical drug)
aged
drug interactions
pregnancy
drug evaluation, preclinical
---
https://www.ema.europa.eu/medicines/human/EPAR/Wakix
2016
false
false
false
United Kingdom
French
English
syndication feed
summary of product characteristics
package leaflet
drug evaluation
piperidines
drug approval
europe
treatment outcome
adult
orphan drug production
narcolepsy
administration, oral
pitolisant
receptors, histamine h3
product surveillance, postmarketing
drug interactions
pregnancy
breast feeding
drug evaluation, preclinical
pitolisant
piperidines
pitolisant
---
http://www.has-sante.fr/portail/jcms/c_2656361/fr/wakix
2016
false
false
false
France
French
piperidines
treatment outcome
adult
orphan drug production
narcolepsy
administration, oral
pitolisant
receptors, histamine h3
insurance, health, reimbursement
evaluation of the transparency committee
Narcolepsy-Cataplexy syndrome
Narcolepsy without cataplexy (disorder)
pitolisant
piperidines
pitolisant
---
http://www.has-sante.fr/portail/jcms/c_2656361/fr/wakix-pitolisant-antagoniste/agoniste-inverse-des-recepteurs-h3-a-l-histamine
2016
false
false
false
France
French
guidelines for drug use
evaluation of the transparency committee
administration, oral
treatment outcome
insurance, health, reimbursement
pitolisant
histamine h3 antagonists
histamine h3 antagonists
narcolepsy
orphan drug production
pitolisant
pitolisant
piperidines
piperidines
---