aplaviroc - CISMeF

Preferred Label : aplaviroc;

MeSH note : a spiro-diketo-piperazine; a potent noncompetitive allosteric antagonist of the CCR5 receptor with concomitantly potent antiviral effects for HIV-1; structure in first source;

CISMeF synonym : 873140 compound; APL compound; 4-((4-(((3R)-1-butyl-3-((R)-cyclohexyl(hydroxy)methyl)-2,5-dioxo-1,4,9-triazaspiro(5.5)undec-9-yl)methyl)phenyl)oxy)benzoic acid hydrochloride; GW873140;

MeSH synonym : benzoic acid, 4-(4-(((3R)-1-butyl-3-((R)-cyclohexylhydroxymethyl)-2,5-dioxo-1,4,9- triazaspiro(55)undec-9-yl)methyl)phenoxy)-;

Is substance : O;

UNII : 98B425P30V;

InChIKey : GWNOTCOIYUNTQP-FQLXRVMXSA-N;

Details

Origin ID

C499671;

UMLS CUI

C1567923;

Currated CISMeF NLP mapping
- Aplaviroc [NCIt concept]
MeSH indexing information
- hiv fusion inhibitors [MeSH Descriptor]
MeSH term(s) associated for indexing
- benzoates [MeSH Descriptor]
- diketopiperazines [MeSH Descriptor]
- piperazines [MeSH Descriptor]
- spiro compounds [MeSH Descriptor]
Pharmacological action(s)
- hiv fusion inhibitors [MeSH Descriptor]
Record concept(s)
- 4-((4-(((3R)-1-butyl-3-((R)-cyclohexyl(hydroxy)methyl)-2,5-dioxo-1,4,9-triazaspiro(5.5)undec-9-yl)methyl)phenyl)oxy)benzoic acid hydrochloride [MeSH concept]
- GW873140 [MeSH concept]
- aplaviroc [MeSH concept]
- rac-4-(4-((1-butyl-3-(cyclohexyl(hydroxy)methyl)-2,5-dioxo-1,4,9-triazaspiro(5.5)undec-9-yl)methyl)phenoxy)benzoic acid [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Aplaviroc [NCIt concept]

Keyword's position in hierarchy(ies) :

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