Preferred Label : EAFP2 peptide, eucommia ulmoides;
MeSH note : the tertiary structure of EAFP2 represents the first five-disulfide cross-linked structural
model of the plant antifungal peptide; adopts a compact global fold composed of a
3(10) helix (Cys3-Arg6), an alpha-helix (Gly26-Cys30), and a three-strand antiparallel
beta-sheet (Cys16-Ser18, Tyr22-Gly24, and Arg36-Cys37); shows a chitin-binding domain
(residues 11-30) with a hydrophobic face and a characteristic sector formed by the
N-terminal 10 residues and the C-terminal segment cross-linked through the unique
disulfide bond Cys7-Cys37, which brings all four positively charged residues (Arg6,
Arg9, Arg36, and Arg40) onto a cationic face; amino acid sequence in first source;
MeSH synonym : Eucommia antifungal peptide 2, E ulmoides;
Is substance : O;
Origin ID : C488625;
UMLS CUI : C1455636;
MeSH term(s) associated for indexing
- Record concept(s)
- Semantic type(s)
