tozasertib - CISMeF

Preferred Label : tozasertib;

MeSH note : a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth; structure in first source;

CISMeF synonym : VE 465; cyclopropane carboxylic acid(4-(4-(4-methylpiperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-ylsulfanyl)phenyl)amide; VX680; MK-0457;

MeSH synonym : N-(4-((4-(4-methylpiperazin-1-yl)-6-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)sulfanyl)phenyl)cyclopropanecarboxamide; cyclopropane carboxylic acid N-(4-(4-(4-methylpiperazin-1-yl)-6-(5-methyl-2H-pyrazol-3-ylamino)pyrimidin-2-ylsulfanyl)phenyl)amide;

MeSH hyponym : VE465 cpd; VE-465; VX-680 lactate; VX-680; MK0457; N-(4-((4-(4-methylpiperazin-1-yl)-6-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)sulfanyl)phenyl)cyclopropanecarboxamide lactate; N-(4-((4-(4-methylpiperazin-1-yl)-6-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)sulfanyl)phenyl)cyclopropanecarboxamide, (2S)-2-hydroxypropanoate;

MeSH Related Number : CN8EF9N084;

Registry Number MeSH : 639089-54-6;

Is substance : O;

UNII : 234335M86K;

Details

Origin ID

C484810;

UMLS CUI

C3273787;

MeSH indexing information
- protein kinase inhibitors [MeSH Descriptor]
MeSH term(s) associated for indexing
- cyclopropanes [MeSH Descriptor]
- piperazines [MeSH Descriptor]
- pyrazoles [MeSH Descriptor]
- pyrimidines [MeSH Descriptor]
Record concept(s)
- MK-0457 [MeSH concept]
- VE 465 [MeSH concept]
- VX680 [MeSH concept]
- VX680 lactate [MeSH concept]
- tozasertib [MeSH concept]
- tozasertib lactate [MeSH concept]
See also inter- (CISMeF)
- Tozasertib [NCIt concept]
Semantic type(s)
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Tozasertib [NCIt concept]

Keyword's position in hierarchy(ies) :

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