MeSH note : an extracellular sulfatase which is a candidate developmental regulator of heparan
sulfate proteoglycan sulfation in embryonic progenitor lineages. It has an enzymatic
domain which functions in the lysosomal degradation of heparan sulfate. It is a heparan
sulfate-specific 6-0 endosulfatase with a high degree of substrate specificity for
6-O-sulfated disaccharides of HS chains of HSPG.;