MeSH note : a small proportion of patients with chronic myeloproliferative diseases have constitutive
activation of the gene for platelet-derived growth factor receptor beta (PDGFRB),
which encodes a receptor tyrosine kinase. The gene is located on chromosome 5q33,
and the activation is usually caused by a t(5;12)(q33;p13) translocation associated
with an ETV6-PDGFRB fusion gene; has been sequenced;