3'-deamino-3'-hydroxydoxorubicin

Preferred Label : 3'-deamino-3'-hydroxydoxorubicin;

MeSH note : substitution of the basic amino group at the C-3' of doxorubicin by a hydroxyl group overcomes recognition of the multidrug resistant P-glycoprotein and limits cardiotoxicity; structure given in first source;

CISMeF synonym : 3'-deamino-4'-epi-3'-hydroxydoxorubin;

MeSH synonym : hydroxyrubicin; 3-DHD;

MeSH CAS label : 5,12-Naphthacenedione, 10-((2,6-dideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, (8S-cis)-;

Registry Number MeSH : 73113-90-3;

Is substance : O;

Details

Origin ID

C042907;

UMLS CUI

C0046799;

MeSH indexing information
- DNA topoisomerases, type II [MeSH Descriptor]
MeSH term(s) associated for indexing
- epirubicin [MeSH Descriptor]
Pharmacological action(s)
- antineoplastic agents [MeSH Descriptor]
- enzyme inhibitors [MeSH Descriptor]
- topoisomerase II inhibitors [MeSH Descriptor]
Record concept(s)
- 3'-deamino-3'-hydroxydoxorubicin [MeSH concept]
- 3'-deamino-4'-epi-3'-hydroxydoxorubin [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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