sirtuin 1 - CISMeF

Preferred Label : sirtuin 1;

MeSH definition : A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in gene regulation.;

MeSH synonym : silent mating type information regulation 2 homolog 1; Sirt1;

Registry Number MeSH : EC 3.5.1.-;

Is substance : O;

Details

Origin ID

D056564;

UMLS CUI

C2720167;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- NAD-Dependent Deacetylase Sirtuin-3, Mitochondrial [NCIt concept]
- NAD-Dependent Protein Deacetylase Sirtuin-1 [NCIt concept]
- SIRT1 Gene [NCIt concept]
- Sirtuin 1 [OMIM gene]
- sirtuin 1 [HGNC gene]
Indexing information
- (2,5-dihydroxyphenyl)(5-hydroxybenzofuran-3-yl)methanone [MeSH Supplementary Concept]
- 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide [MeSH Supplementary Concept]
Record concept(s)
- sirtuin 1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- SIRT1 protein, human [MeSH Supplementary Concept]
- Sirt1 protein, mouse [MeSH Supplementary Concept]
- Sirt1 protein, rat [MeSH Supplementary Concept]
- sirt1 protein, zebrafish [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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