Preferred Label : insulin receptor substrate proteins;
MeSH definition : A structurally-related group of signaling proteins that are phosphorylated by the
INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share in common an N-terminal
PHOSPHOLIPID-binding domain, a phosphotyrosine-binding domain that interacts with
the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine
phosphorylation insulin receptor substrate proteins interact with specific SH2 DOMAIN-containing
proteins that are involved in insulin receptor signaling.; A structurally-related group of signaling proteins that are phosphorylated by the
INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN
HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated
INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation,
insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins
that are involved in insulin receptor signaling.;
MeSH synonym : IRS signaling adaptor proteins;
MeSH hyponym : insulin receptor Substrate-3 protein; insulin receptor Substrate-1 protein; insulin receptor Substrate-2 protein; insulin receptor Substrate-4 protein; Insulin Receptor Substrate 1 Protein; Insulin Receptor Substrate-1; Insulin Receptor Substrate 1; Insulin Receptor Substrate 4 Protein; Insulin Receptor Substrate-4; Insulin Receptor Substrate 4; Insulin Receptor Substrate 2 Protein; Insulin Receptor Substrate-2; Insulin Receptor Substrate 2; Insulin Receptor Substrate 3 Protein; Insulin Receptor Substrate-3; Insulin Receptor Substrate 3;
Wikipedia link : https://en.wikipedia.org/wiki/Insulin receptor substrate 1;
Is substance : O;
Origin ID : D055504;
UMLS CUI : C2350409;
Allowable qualifiers
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A structurally-related group of signaling proteins that are phosphorylated by the
INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share in common an N-terminal
PHOSPHOLIPID-binding domain, a phosphotyrosine-binding domain that interacts with
the phosphorylated INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine
phosphorylation insulin receptor substrate proteins interact with specific SH2 DOMAIN-containing
proteins that are involved in insulin receptor signaling.
A structurally-related group of signaling proteins that are phosphorylated by the
INSULIN RECEPTOR PROTEIN-TYROSINE KINASE. The proteins share an N-terminal PLECKSTRIN
HOMOLOGY DOMAIN, a phosphotyrosine-binding domain that interacts with the phosphorylated
INSULIN RECEPTOR, and a C-terminal TYROSINE-rich domain. Upon tyrosine phosphorylation,
insulin receptor substrate proteins interact with specific SH2 DOMAIN containing proteins
that are involved in insulin receptor signaling.
